Lumigan

lumigan
Lumigan (bimatoprost)

Buy Lumigan Online

Today, prostaglandin analogs are probably the most commonly prescribed glaucoma agents in the United States. Compared to most other intraocular pressure-lowering drugs, the prostaglandins require less frequent dosing and create substantially fewer systemic side-effects. If you've received a prescription for Lumigan ophthalmic solution, your doctor has decided to prescribe this specific medication for you. Buy Lumigan, an FDA-approved eyedrop medication online, prescribed to lower high eye pressure in patients with open-angle glaucoma or ocular hypertension. The most common treatment to lower high eye pressure an important, treatable risk factor in glaucoma patients is with prescription eyedrops, such as Lumigan ophthalmic solution. Lumigan is for people who have a specific type of glaucoma, known as open-angle glaucoma, or for people who have ocular hypertension. Although the exact way Lumigan may work is unknown, it is thought to increase the outflow of aqueous humor, helping it to drain through 2 separate pathways out of the eye.

How should I use Lumigan

The usual dose of Lumigan eye drops is 1 drop into the affected eye every evening. Follow your doctor's dosing instructions very carefully. Do not use this medicine while wearing contact lenses. Lumigan may contain a preservative that can discolor soft contact lenses. Wait at least 15 minutes after using this medicine before putting in your contact lenses. Wash your hands before using the eye drops.

To apply the Lumigan eye drops:

  • Tilt your head back slightly and pull down your lower eyelid to create a small pocket. Hold the dropper above the eye with the tip down. Look up and away from the dropper and squeeze out a drop.
  • Close your eyes for 2 or 3 minutes with your head tipped down, without blinking or squinting. Gently press your finger to the inside corner of the eye for about 1 minute, to keep the liquid from draining into your tear duct.
  • Wait at least 5 minutes before using any other eye drops your doctor has prescribed.

Do not touch the tip of the eye dropper or place it directly on your eye. A contaminated dropper can infect your eye, which could lead to serious vision problems. Do not use Lumigan eye drops if the liquid has changed color or has particles in it. Call your pharmacist for new medicine.

Glaucoma

Glaucoma is a slowly progressing disorder in which the pressure inside the eye gradually increases. If left untreated, this elevated pressure may lead to nerve damage, decreased vision, and blindness. In general, the higher the pressure inside the eye, the greater the chance of damaging the optic nerve (the nerve to the eye that allows us to see) and losing vision. Most people with glaucoma have no symptoms until extensive, irreversible damage to the optic nerve has occurred, so it is important to have regular eye exams as you grow older. It is also important to take your medicine regularly if you have glaucoma.

To understand what causes glaucoma, it helps to start by discussing how the eye normally works. The eye can be divided into three parts. The vitreous chamber is the large, round area behind the lens. The posterior chamber is the smaller area located behind the iris and in front and to the sides of the lens. The anterior chamber is located in front of the iris. Both the anterior and the posterior chambers are filled with a clear liquid called the aqueous humor. Normally, aqueous humor flows from the posterior chamber through the opening in the iris to the anterior chamber. It leaves the eye through a small opening, called the canal of Schlemm, at the outermost edges of the iris. In glaucoma, less aqueous humor drains from the eye, raising the pressure inside the eye. The disorder is similar to blowing up a balloon: if there is no opening for the air to flow out, the pressure in the balloon steadily increases as the balloon fills with air.

Elevated pressure inside the eye can be treated in two ways:

  • increasing the amount of aqueous humor that leaves the eye through the canal of Schlemm; or
  • decreasing the amount of aqueous humor that is produced.

A prostaglandin-containing drug Lumigan (bimatoprost) is now the most widely used eye-drop product for treating glaucoma. A combination of drugs may be necessary for more severe forms. Surgery is reserved for those people who continue to have optic nerve destruction and visual loss, in spite of multiple drug therapies.

Application of Lumigan Eye Drops; Glaucoma

The normal eye can hold about 10 microliters (10 millionths of a quart) of liquid. A single drop formed by an eye dropper, however, ranges from 25 to 50 microliters. What happens to the excess 15 to 40 microliters when you apply eye drops? Two things occur:

  1. Medicine overflows the eyelids and runs down your face, especially if you are upright when applying the drops. This is not a very efficient use of medicine but is relatively harmless.
  2. Medicine drains from the eyes into a small opening located at the inside corner of the eye. This small opening is the entrance to a duct (the nasolacrimal duct) through which tears and moisture normally leave the eye and drain into the nose (which is why your nose usually runs when you cry). In the nose, the medicine is absorbed into the blood supply and carried throughout the body, where it can affect the brain, heart, digestive system, lungs and airways, and other areas of the body, causing adverse effects.

What can be done to maximize drug absorption in the eye and minimize drug absorption through the nasal blood vessels?

  1. Do not apply more than one drop of medicine within a five-minute period, regardless of whether the second drop is the same or a different drug. The eye cannot hold more than one drop at a time, so an extra drop both flushes out the first drop and is diluted by it. It also increases the amount that is absorbed through the nasal blood vessels. Therefore, always wait at least five minutes between drops to give adequate time for the drug to be absorbed by the eye.
  2. Lie down when applying drops. This helps to prevent “tears” from rolling down your face and through the nasolacrimal duct. As much as 10 times more drug is lost when you are in an upright position than when you are reclining.
  3. Using your thumb and middle finger (one in the corner of each eye), apply gentle pressure to the inside corner of the eye for five minutes after applying each drop, to block the medicine from draining through the nasolacrimal duct.

Compressing the duct for five minutes allows enough time for the drug to be absorbed through the eye and decreases adverse effects.

To avoid contaminating the eye drops, do not touch the applicator tip to any surface, including the eye. Store the bottle tightly closed. To ensure sterility, periodically discard used bottles of medicine. Drops can be considered safe for four weeks and ointments for three months after they have been opened.

To apply drops, first wash your hands. To increase drug absorption, it is best to lie down while applying this medicine. With the middle finger of the hand on the same side as the eye (right eye, right hand, for example), apply pressure to the inside corner of your eye to block the drainage duct. After you have begun to apply pressure with your middle finger, tilt your head back. With the index finger of the same hand, pull the lower eyelid away from the eye to form a pouch. Place a drop of medicine into the pouch, remove the index finger, and close your eyes gently, without blinking. Keep your eyes closed and continue to apply pressure for five minutes. Do not close your eyes tightly and do not blink.

How can Glaucoma be treated with Lumigan?

Open-angle glaucoma is one of several kinds of glaucoma (a condition that leads to vision loss). Glaucoma is the result of damage to your optic nerve (the nerve that sends images to your brain). Over time, this damage can cause you to lose the ability to see. Open-angle glaucoma develops slowly, and most people are not aware of any symptoms. Your eye doctor can check to see if your optic nerve is being damaged. Glaucoma usually happens in both eyes, but one eye may be worse than the other. A first symptom of glaucoma you may notice is difficulty with your side vision. It may also be difficult to see things in bright light or when you go between light and dark. Without treatment, your field of vision gets less and less until you cannot see at all. Your eye doctor can do tests to check for glaucoma. This is why it is important to see your eye doctor regularly. Open-angle glaucoma is the result of damage to your optic nerve. One thing that can damage your optic nerve is an increase in the pressure in your eyes. Some people's optic nerves are more sensitive to an increase in pressure than other people's. Your eye pressure may be at a level considered normal, and you can still have damage to your optic nerve. Increased pressure can happen if the fluid inside your eyes is not draining properly. Your eyes are always making and draining fluid. This fluid keeps the pressure in your eyes at the correct level so they stay the right shape so you can see. Fluid drains from your eyes through a drainage system between the iris and cornea. In people with open-angle glaucoma, the angle to the canals is open, but the fluid is not draining properly. There may be several reasons why your eyes are not draining fluid properly. The canals may be too narrow, or they may be blocked. If fluid cannot drain out, then it builds up inside your eyes. This could increase the pressure inside your eyes. If the pressure becomes too high for your eyes, it can damage your optic nerve and decrease your ability to see.

FDA-approved prostaglandins Lumigan (Allergan). Prostaglandins. These glaucoma eye drops often have the best user compliance because they are required only once daily. Prostaglandins generally work by relaxing muscles in the eye's interior structure to allow better outflow of fluids, thus reducing buildup of eye pressure. Glaucoma eye drops are classified by the active ingredient chemical that helps make the drug work. Also, many of the glaucoma eye drops are available in generic forms at online pharmacy.

Benefits

What benefit has Lumigan shown during the studies?

Lumigan 0.3 mg/ml on its own was more effective than timolol at reducing eye pressure. This effect was maintained after two or three years of treatment, with an average reduction in eye pressure of between 7.1 and 8.6 mmHg with Lumigan used once a day, compared with 4.6 to 6.4 mmHg with timolol. Lumigan 0.3 mg/ml was also more effective than latanoprost, with patients using Lumigan achieving a reduction in eye pressure of 6.0 to 8.2 mmHg after six months of treatment compared with 4.9 to 7.2 mmHg with latanoprost. Adding Lumigan 0.3 mg/ml to existing treatment with a beta-blocker was more effective than continuing to use the beta-blocker on its own. After three months, eye pressure was lowered by 7.4 mmHg in the group adding Lumigan, compared with 3.6 mmHg in the group adding placebo. Lumigan was as effective as latanoprost when added to beta-blocker treatment, with reductions in eye pressure of 8.0 and 7.4 mmHg, respectively, after three months. Lumigan 0.1 mg/ml brought about slightly smaller decreases in IOP than Lumigan 0.3 mg/ml. However, the lower strength formulation was better tolerated and was less likely to cause hyperaemia (redness of the eye).

One of Lumigan benefits are that drops are very effective for treating glaucoma. The Committee for Medicinal Products for Human Use (CHMP) decided that Lumigan's benefits are greater than its risks and recommended that it be given marketing authorisation.