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Z-endoxifen, a potent derivative of the drug tamoxifen, induced tumor shrinkage in women with ER-positive metastatic breast cancer who had progressed on standard anti-estrogen therapies. In results recently published online in the Journal of Clinical Oncology, investigators led by Matthew Goetz, MD, professor of oncology at Mayo Clinic in Rochester, found that Z-endoxifen had acceptable toxicity and "provides substantial drug exposure unaffected by CYP2D6 metabolism." Read More