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Nolvadex (Tamoxifen)

Nolvadex as the highest form of gyno treatment

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Tamoxifen (Generic Nolvadex)

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Currently, Nolvadex is the gold standard in the treatment of hormone-dependent breast cancer - it reduces the risk of tumor recurrence by more than 40%. This is a very important drug that is recommended to women who have been cured of breast cancer for many years as maintenance hormone therapy. And one of its main advantages is its low price. It may not be the best among such drugs, but it is definitely the cheapest.

Tamoxifen (Nolvadex) is an effective hormone therapy used to treat hormone receptor-positive breast cancer in the United States. It can significantly reduce the risk of cancer recurrence and invasive cancer. Some people take tamoxifen to lower their risk of developing breast cancer. Daily oral treatment stops cancer cells from using estrogen and progesterone to grow and spread.

Tamoxifen is one of the earliest anti-tumor targeting drugs and, as a consequence, the most studied. It began to be used in the late 1970s for metastatic breast cancer, and 10 years later it became the standard of adjuvant therapy after radical treatment. This is the reason why the results of clinical trials with a follow-up period of 20 years are appearing, which most of the innovative molecules that entered clinical practice during the last decade cannot boast of. Tamoxifen was, is and will remain the standard option for adjuvant hormone therapy in patients with ER-positive breast cancer.

Nolvadex Tamoxifen Mechanism Of Action

Nolvadex is a type of hormone therapy known as a selective estrogen receptor modulator (SERM). The drug attaches to hormone receptors (specific proteins) in breast cancer cells. Once the drug gets inside the cells, it stops the cancer from accessing the hormones it needs to reproduce and grow. Its action is based on the ability to block estrogen receptors: Tamoxifen and some of its metabolites compete with estradiol for binding sites with cytoplasmic estrogen receptors in breast, uterine, vaginal and anterior pituitary gland tissues and tumors with high estrogen receptor content. In contrast to estrogen, tamoxifen, binding to estrogen receptors, does not affect DNA synthesis in the nucleus, but inhibits cell division, which leads to regression of tumor cells by their death.

What are the other benefits of taking tamoxifen?

In addition to reducing the risk of breast cancer and cancer recurrence, tamoxifen

  • Prevents loss of bone mass after menopause
  • Reduces cholesterol levels

Nolvadex (tamoxifen) is a more preferred embodiment, compared Clomid. Read more about clomid at Nolvadex is normally given to patients who have undergone surgery for breast cancer to prevent tumours growing back. But clinics wich pioneering its use in fertilty treatment to help women over 40 who have a limited number of eggs. Early trials have shown that if these women were given Tamoxifen, approximately one in five were able to have a baby using their own eggs. The tablets are taken to gently mature a few eggs but the drug also has a favourable effect on the lining of the uterus, causing it to thicken so that the embryo has the best chance of implantation.

How to get Nolvadex (tamoxifen) pharmacological effect

Nolvadex (tamoxifen)

Nolvadex can help women and men with hormone-receptor breast cancer. The drug can reduce the risk of developing breast cancer in women. It should be taken:

  • Women who are at high risk of developing breast cancer because of a family history of the disease or mutated (changed) breast cancer (BRCA) genes.
  • Patients who have already been diagnosed with breast cancer, to prevent a recurrence (return) of the cancer.

The dosing regimen is usually set individually depending on the indication. The daily dose is 20-40 mg. As a standard dose, we recommend taking 20 mg of oral tamoxifen daily for a long time. If there are signs of disease progression, the drug should be discontinued.

How long should I take Nolvadex?

Most people take Nolvadex or other hormone therapy for at least five years and sometimes up to 10 years. The length of treatment depends on the individual characteristics of the cancer. Your doctor may recommend taking tamoxifen for five years and then switching to another hormone therapy for a few more years.

Nolvadex for PCT

The benefits of taking nolvadex during post cycle therapy. What does nolvadex do? When you're loading up on anabolic steroids, the body is conditioned to put off its production of androgens or male hormones, particularly testosterone. To offset this lack of androgens, the body boosts its production of estrogen. Uncontrolled estrogen surges can also increase your risks of developing health problems like prostate disease, stroke, cardiovascular issues and loss of bone mineral density, which makes you more vulnerable to fractures, if not corrected in the soonest time. Strong steroid drugs used by bodybuilders can have a negative effect on the body. That is why experts recommend buying Tamoxifen. This is a modern remedy that minimizes the risks of unpleasant consequences after a course of steroids.

Nolva - Bodybuilding

Nolvadex therapy alone may resolve physiological gynaecomastia. Tamoxifen is an effective treatment for physiological gynaecomastia, especially for the lump type. The popularity of the drug is due to the fact that the positive effect appears almost immediately after the start of admission. The active ingredient is quickly absorbed in the body and transported by blood to the muscle tissues. Among the most significant pluses of application are worth noting:

  • Instant reduction of aromatization
  • Reduction of estrogen levels in the blood
  • Relief of edema, which often develops in the musculature
  • Significant slowing or complete reduction in the growth of fatty deposits
  • Decrease in blood pressure, which often rises due to water retention
  • Dryness and relief of the muscles
  • Prevention of the development of gynecomastia

This is why many doctors and professional trainers insist on using Tamoxifen. Another advantage of the drug is its low cost and availability.

What are the side effects of taking Nolvadex?

This drug can increase the risk of very serious, sometimes deadly side effects such as strokes, blood clots, endometrial cancer, or uterine cancer. Side effects can include:

  • Vaginal discharge
  • Headaches
  • Skin rashes
  • Irregular or falling menstruation
  • Swelling of the legs
  • Menopause-like symptoms, including hot flashes, night sweats, and vaginal dryness
  • Nausea
  • Weight gain or swelling
  • Fatigue

Tamoxifen can cause birth defects. You should not take the medicine if you are pregnant or planning to get pregnant. You will need to use contraception while taking tamoxifen and for two months after you stop taking the medicine.

Special features and advantages of using the drug

You should always take Tamoxifen if you want to avoid the side effects of aggressive steroids. Since the latter are often classified as androgenic drugs, they provoke fluid retention and increase female hormone levels to a critical upper limit.

The average dosage of Tamoxifen is 20 to 30 mg per day. Uninterrupted intake is allowed for a period of 3 to 5 weeks. It is not recommended to take the substance longer than that, because there is a possibility of overdose. Before starting the course is recommended to consult a specialist.

If you neglect the advice of physicians, can occur:

  • Headache, migraines
  • Nausea, in rare cases - vomiting
  • Decreased erectile function, decreased libido
  • Increased fatigue
  • Rashes on the face and body resembling teenage acne
  • Decline in visual acuity, which has been noted in rare cases when low-grade medications are used in uncontrolled doses
  • Depression provoked by an abrupt change in the hormonal background

It is easy to avoid negative consequences. You just need to carefully follow the recommendations of doctors and regular check-ups to monitor the level of hormones in the body. In the case of allergic reactions, there is no need to cancel the drug - it is sufficient to find an alternative with other excipients in the composition.

The quality of the substance used also plays an important role. Look for only proven products in online pharmacies, the safety of which is confirmed by the presence of all the necessary certificates.